Horphag Research

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Horphag Research is a global leader in the research, development and commercialization of clinically studied, science-backed botanical ingredients for the nutraceutical, food supplement and beauty-from-within industries.

The company is best known for Pycnogenol® French maritime pine bark extract, one of the world’s most extensively researched natural ingredients. Exclusively sourced from the bark of maritime pine trees grown in southwest France, Pycnogenol® contains a unique combination of procyanidins, bioflavonoids and organic acids.

More than 40 years of research, 160+ clinical studies, 450 scientific publications and 12,000+ study participants support Pycnogenol® across a wide range of health applications. Today, it is used in more than 1,000 finished products worldwide.

Pycnogenol® supports health through several complementary properties, including healthy blood circulation and endothelial function, antioxidant activity, support for a balanced inflammatory response, and connective tissue support. These mechanisms underpin research in areas including cardiovascular and circulatory health, cognitive function, skin health and beauty-from-within, healthy aging, women’s health, sports performance, joint health, eye health and respiratory health.

Horphag Research’s portfolio also includes Robuvit® French oak wood extract, a standardized extract rich in unique oak polyphenols including roburins. Robuvit® has been studied for more than a decade and is now supported by 25+ clinical studies involving more than 1,400 subjects. Research demonstrates benefits in areas including natural energy, vitality, fatigue management, sports performance and recovery, healthy aging and cellular energy metabolism.

The company’s third branded ingredient, Centellicum®, is a standardized Centella asiatica extract developed for connective tissue, skin and vascular support. Clinical research investigates its effects on microcirculation, collagen remodeling, skin regeneration and venous health.

Together, Horphag Research’s ingredients are backed by 230+ clinical studies involving more than 15,000 subjects, providing formulators with a strong scientific foundation for differentiated products across today’s key health and wellness categories.

Horphag Research works closely with manufacturers and brand owners worldwide, providing scientific, technical, regulatory, formulation and marketing support throughout the product-development process. Its approach is based on long-term investment in ingredient-specific research, consistent quality and meaningful consumer benefits.

At Fi Europe, discover how Pycnogenol®, Robuvit® and Centellicum® can support your next science-backed product innovation.

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Pycnogenol®

Pycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits.  Pycnogenol®'s 4...

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Centellicum®

Centellicum® is a patented, natural, and standardized extract of the plant Centella asiatica (also known as Gotu Kola) used in supplements to aid in the healing and remodelling of scars, stretch marks, and tissues. It promotes collagen synthesis and tissue regeneration, and studies have shown it ...

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Robuvit®

Robuvit® (row-boo-vit) is a patented natural extract of French oak wood, rich in roburins and other flavonoids unique to oak wood. Robuvit® is a powerful, premium quality and natural vitality ingredient. Thanks to its unique properties, Robuvit® has been shown to offer potential health ...

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News about Horphag Research

3 Sep 2026

Clinical Trial Shows Pycnogenol® Significantly Relieves Lipedema Symptoms and Improves Quality of Life in Women

A double-blind, placebo-controlled study in 100 women with lipedema found that 150 mg Pycnogenol® daily for 60 days reduced overall symptoms by 29%, including leg swelling, heaviness, tenderness and bruising. Participants also reported improved quality of life and leg appearance, with no adverse effects reported. The findings suggest Pycnogenol® may offer a natural, non-invasive option to support lipedema symptom management.

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What is Pycnogenol® ? ...and what is it good for?