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Consumer Study Confirms the Efficacy and Tolerability of Xorialyc® for Sensitive and Irritated Skin

Xorialyc® is a next-generation olive leaf extract (300 mg/day). In a 60-day consumer study with 50 adults (40–60 y), it reduced redness (74%), itching (76%), tightness (72%) and improved skin hydration and quality (~72%). 80% noticed visible effects, 78% said it worked fast and would recommend it. Its activity comes from luteolin, quercetin and ortho-diphenols, which inhibit NF-κB, COX-2 and PGE₂ while providing strong antioxidant protection.

Consumer Study Confirms the Efficacy and Tolerability of Xorialyc® for Sensitive and Irritated Skin Date: April 9, 2025

Xorialyc®, Pharmactive’s next-generation olive leaf extract, is positioning itself as a premium botanical solution for inflammatory skin concerns such as redness, itching, tightness, and discomfort. While often perceived as only an aesthetic issue, skin inflammation has deeper consequences, directly affecting emotional wellbeing and self-confidence.

Environmental aggressors like pollution, UV exposure, wind, as well as topical irritants and impaired skin barrier function are increasingly linked to skin sensitivity. As a result, the demand for natural, effective, and well-tolerated solutions has never been higher.

Real-World Evidence: 60-Day Consumer Study To validate Xorialyc®’s effects in daily life, Pharmactive conducted a consumer perception study with 50 healthy adult volunteers (men and women, aged 40–60, average age 48). All participants reported baseline discomforts such as redness, itching, tightness, and irritation, but were not under dermatological treatments or taking other supplements.

Each participant consumed one capsule per day containing 300 mg of Xorialyc®. Outcomes were assessed before and after 60 days using standardized questionnaires.

Key Findings:

- 76% reported reduced itching

- 74% experienced less facial redness and inflammation

- 74% noticed improved skin hydration

- 72% felt reduced skin tightness

- 72% reported overall better skin quality

- 80% observed visible effects

- 78% stated that Xorialyc® works quickly

 - 78% would recommend it

- 74% found it more effective than previous products they had tried

These results highlight both the high tolerability and consumer satisfaction, confirming Xorialyc®’s potential as a natural, long-term solution for common skin complaints.

Botanical Science Behind the Results The efficacy of Xorialyc® lies in its unique composition and standardization:

≥ 0.1 mg/g of luteolin-7-O-glucoside, protocatechuic acid, and quercetin (analyzed by HPLC)

≥ 20% ortho-diphenols (measured by UV)

These bioactive compounds are well-recognized for their antioxidant and anti-inflammatory properties.

In in-vitro studies, Xorialyc® demonstrated that it:

Inhibits the NF-κB pathway, a master regulator of inflammation

Downregulates inflammatory gene expression such as COX-2

Reduces PGE₂ production, a key pro-inflammatory molecule

Shows strong antioxidant capacity, helping to restore balance in skin exposed to oxidative stress

Thanks to this multifaceted mechanism, Xorialyc® works from within to calm and restore sensitive skin, targeting the root causes of inflammation.

Consumer Perception by Gender The study also revealed distinct consumer expectations:

Women prioritized improvements in skin hydration and overall quality.

Men, often more affected by shaving-related irritation, looked for relief from itching and redness.

These insights can help brands tailor both formulations and marketing strategies to different target audiences.

Natural. Effective. Reliable. As consumer demand for clean-label, plant-based ingredients backed by science continues to grow, Xorialyc® stands out for its unique positioning:

Derived from Olea europaea L. (olive leaf).

Premium standardization with traceable actives.

Supported by scientific and consumer evidence.

Suitable for nutricosmetics, dermaceuticals, and “beauty-from-within” concepts.

Contact & Further Information

For collaboration opportunities, technical documentation, or free samples: [email protected]

Pharmactive Biotech Products, S.L. is a Spanish company dedicated to developing and manufacturing differentiated, science-backed natural ingredients for the nutraceutical, pharmaceutical, and veterinary industries.

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