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NXT USA’s proprietary Digexin formula relieves upset gut in GLP-1 patients

10 Apr 2026

Research indicates that NXT USA’s proprietary formulation, Digexin, addresses various types of gastrointestinal (GI) issues in adults prescribed GLP-1 receptor agonist therapy.

Key ingredients

Digexin features a proprietary blend of okra fruit (Abelmoschus esculentus) and ashwagandha root (Withania somnifera).

These botanicals synergistically support gut health through complementary mechanisms. Okra’s soothing polysaccharides coat and hydrate the intestinal lining, promoting smoother digestion. Meanwhile, ashwagandha root helps the body recalibrate stress responses by lowering cortisol levels and supporting serotonin production.

Clinical benefits

NXT USA says this dual action targets the “interplay between stress and digestion” — helping normalise bowel rhythms, reduce discomfort, and restore balance in seven days.

Eric Anderson, managing director of NXT USA, says these results support Digexin’s potential to complement GLP-1 drugs as it helps to reduce side effects and supports overall well-being.

Clinical study findings

The open-label study included patients experiencing various GI side effects who were taking oral semaglutide, the generic name for GLP-1 drugs like Ozempic or Rybelsus.

For three weeks, the subjects supplemented with Digexin and researchers monitored them for changes in GI comfort and overall well-being.

Participants reported “meaningful improvements” in digestive comfort and function, including reduced constipation, reflux, and swallowing difficulties. They also had more regular and complete bowel movements.

Beyond digestive outcomes, subjects taking Digexin also experienced improvements in sleep quality, reduced perceived stress, and “greater overall quality of life.” The supplement was well tolerated, and no adverse events were reported.

Market impact

“We are not about activating GLP-1 activity,” says Anderson. “Digexin addresses GLP-2 — as in No. 2. That is, constipation that results from dieting strategies. Our research is built on rigorous, reproducible human clinical trials designed for real-world application. Digexin delivers results that consumers can trust and brands can build on.”

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