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Affron® once again proves its effectiveness: a new clinical study confirms its positive impact on emotional balance

A new large-scale clinical study, published in The Journal of Nutrition (May 2025), has confirmed that Affron®, Pharmactive’s standardized saffron extract, can help improve emotional balance in individuals experiencing symptoms of low mood. With over 200 participants, this is the most ambitious study conducted with this ingredient to date.

Clinical Study Summary: Affron® for Emotional Wellbeing

A recent study in adults with symptoms of mild depression — a common and often underdiagnosed condition — confirms the efficacy of Affron®, a standardized saffron extract (Crocus sativus L.), in improving emotional wellbeing.

Key results (12 weeks, 28 mg/day):

72% of participants taking Affron® reported significant emotional improvement (vs. 54% with placebo).

Average 53% reduction in emotional symptom scores (DASS-21 scale).

Benefits became noticeable as early as week five.

Clear improvements in sleep quality among those with poor baseline sleep.

What makes Affron® unique:

Clinically standardized with 3.5% Lepticrosalides®.

Fast-acting: detectable effects within the first hour.

Low effective dose: 28 mg/day (or 14 mg before bedtime for sleep support).

Proven safety in adolescents, menopausal women, and adults.

Backed by 11 published clinical studies.

Conclusion: Affron® bridges traditional use and modern science, offering a natural, safe, and clinically proven solution to support mood, reduce stress, and enhance sleep quality.

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