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LAC-Shield (heat-killed Lactobacillus paracasei MCC1849) was selected from the several thousand strains of lactic acid bacteria stocked by Morinaga Milk Industry Co., Ltd. LAC-Shield greatly surpasses the other lactic acid bacteria in immune activity,. It has a high ability to induce the production of interleukin-12 (IL-12) - a cytokine with important regulatory functions, bridging innate and adaptive immunity.