ProGsterol

ProGsterol is a peptide-based nutraceutical developed by Caregen to support glucose metabolism, lipid balance, and overall metabolic health. Its active ingredient, Deglusterol, is a proprietary peptide complex derived from Deobetide and Adiporin, designed to support key metabolic pathways associated with glucose regulation, insulin sensitivity, and fat metabolism.
As a food supplement, ProGsterol is positioned as a science-based health nutrition solution for metabolic balance, particularly relevant for individuals facing lifestyle-related metabolic challenges. By supporting multiple metabolic pathways in a convenient and non-invasive format, it provides a practical approach for early-stage management and long-term maintenance of metabolic health.
ProGsterol has completed the U.S. FDA New Dietary Ingredient (NDI) notification in March 2022, supporting its positioning as a safe, globally compliant, and scientifically validated ingredient for metabolic health applications.
 
Clinical Highlights

• Clinical studies of Deglusterol (ProGsterol) have demonstrated consistent improvements across key metabolic parameters. In individuals with metabolic imbalance, supplementation resulted in reductions in fasting blood glucose (up to -23 mg/dL), fasting insulin (up to -5.2 μU/mL), HOMA-IR (up to -2.3), and HbA1c (up to -0.9%), indicating improved glucose regulation and metabolic efficiency.
• In pre-diabetic populations, a 12-week study showed reductions in fasting blood glucose (-6.7 mg/dL), HbA1c (-0.3%), fasting insulin (-1.03 μU/mL), and HOMA-IR (-0.43), supporting its role in early-stage metabolic management and insulin sensitivity improvement. Additional biomarker data, including C-peptide (-0.12), further supports its impact on metabolic balance.
• In individuals with metabolic syndrome and liver-related metabolic conditions, Deglusterol demonstrated improvements in hepatic status, including reductions in liver fat grade and overall disease severity over a 3-month period, along with positive changes in lipid metabolism.
• ProGsterol has also shown benefits in body composition, including reductions in body weight (-4.63 kg), BMI (-1.73), and waist-to-hip ratio (WHR, -0.11), supporting its role in integrated metabolic and weight management strategies.

ProGsterol is positioned as a core metabolic health solution within the food supplement market, addressing individuals with metabolic imbalance, insulin resistance, and elevated metabolic risk.
Key target segments include pre-diabetic populations, individuals with impaired glucose metabolism, and preventive health consumers seeking long-term metabolic balance and healthy aging.
With increasing demand for science-based, non-pharmaceutical solutions, ProGsterol offers a differentiated and scalable approach aligned with global trends toward preventive and lifestyle-driven health management.