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Ligilactobacillus salivarius PS11610 Enhances IVF Success: FERTIBIOME® | CLINICAL EVIDENCE (2)

9 Mar 2025

Ligilactobacillus salivarius PS11610 enhances the success of fertilisation through IVF: A preliminary retrospective analysis.

Study published in Nutrients (2025)

Abstract

Background/Objectives: Infertility affects couples of reproductive age, with in vitro fertilisation (IVF) being the most effective treatment. IVF success rates are influenced by various factors, including a healthy microbiome in the female reproductive system, which can enhance implantation rates and pregnancy outcomes.

This study assessed the impact of Ligilactobacillus salivarius PS11610 on IVF outcomes. The strain demonstrated antimicrobial activity against pathogens associated with dysbiosis, which is frequently observed in women undergoing assisted reproductive treatments.

Results

Administering L. salivarius PS11610 at a dose of 1 × 10⁹ CFU every 12 hours for at least one month before IVF procedures, particularly in the frozen embryo transfer (FET) group, appears to improve IVF success rates. IVF procedures without embryo transfer showed no significant differences between the groups. However, statistically significant differences in embryo quality were observed, specifically in category 2 embryos, which were higher in the group without L. salivarius PS11610 supplementation (p = 0.042).

Similar results were seen in the IVF with embryo transfer group, where the quality of embryos in categories 2 and 3 was higher in the group without L. salivarius PS11610 (p = 0.019 and p = 0.05, respectively). IVF with FET showed notable improvements, where intake of L. salivarius PS11610 was associated with a significant increase in live birth infants (26.4% with L. salivarius PS11610 vs. 17.9% without, p = 0.034) and higher biochemical pregnancy rates (42.6% vs. 34%, p = 0.071).

Conclusions

While differences in embryo quality were observed, the overall positive impact on pregnancy and birth outcomes underscores L. salivarius PS11610 as a promising supplement for assisted reproductive treatments.

Keywords

in vitro fertilisation; probiotics; Ligilactobacillus salivarius; infertility

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