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Newly published results on Unigen's Symetrian™ for rapid immune activation

Significant clinical study results quantifying rapid immune activation after one dose of UP360 (Symetrian) have been published by NIS Labs in collaboration with Unigen, Inc.  UP360 is marketed under Unigen’s brand name Symetrian™. NIS Labs is a contract research organization (CRO) providing clinical studies and lab assays that help clients support efficacy claims and differentiate their products from competition.  

UP360 is an Aloe-based nutraceutical composition formulated for healthy immune homeostasis. The composition also contains extracts from the Poria cocos mushroom and from rosemary. This is the first study to document the rapid immune activation that happens after consuming a single dose of UP360. The randomized, double-blind, placebo-controlled, cross-over clinical trial involving supplementation with UP360 provides evidence for a rapid mobilization of immune cells, specifically those cells that are involved in the immediate (“innate”) immune protection when encountering a pathogen.

“The UP360 nutraceutical formulation was studied using our unique and highly controlled study design for evaluating changes within the immune system within hours of consuming a single dose of a natural product,” says Dr. Gitte Jensen, founder and research director at NIS Labs. “Highly significant changes in immune activation and surveillance activity were documented starting at 1 hour, with downstream effects seen at 2 and 3 hours. These changes are rapid and transient, as the immune system returns to homeostasis.”

The results were published in PLoS One, “Rapid increase in immune surveillance and expression of NKT and γδT cell activation markers after consuming a nutraceutical supplement containing Aloe vera gel, extracts of Poria cocos and rosemary. A randomized placebo-controlled cross-over trial.” The trial involved 11 healthy participants, consuming UP360 on one clinic visit and placebo on the other clinic visit. On each visit, a period of rest was followed by a baseline blood draw and consuming a test product. Additional blood draws were performed at 1, 2, and 3 hours after consuming a product. The results showed rapid increases immune surveillance and alertness, increased levels of chemokines and the stem cell-mobilizing growth factor G-CSF, and increased enzymatic activity for the body’s own antioxidant enzymes superoxide dismutase and catalase.

Unigen Chief Scientific Officer, Dr. Qi Jia, stated, “This study is pivotal in documenting that a single dose of UP360 supports and activates the natural defense of the immune system in protecting our body. The waves of immune activation through cytokine releases, in combination with the waves of immune cell migration, suggests a highly coordinated sequence of events after consuming UP360.” Dr. Jia explained that the initial wave is associated with release of chemokines, followed by immune cell activation. The third wave involves highly significant migration of natural killer cells, CD8+ T cells and γδ T cells, parts of our innate immune defense system. “Because we applied a study design that is able to capture these rapid events, we were able to demonstrate this unique effect of consuming UP360.”

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