The Diamod® system

The Diamod® system is a cutting-edge technology for biorelevant in vitro analysis of the bioavailability and pharmacokinetics of small molecule drugs, especially to measure dissolution and permeation of poorly soluble but permeable (BCS-class II) compounds. By design, the Diamod® recreates the physical interconnection of the dissolution and permeation processes by fully reproducing the dynamic environment of the upper gastrointestinal compartments. Unlike other models, the Diamod® is able to dynamically simulate all factors influencing dissolution and permeation in function of time (including pH, flux rates, secretions and concentrations of enzymes, and the concentration of the drug), reflecting the biological complexity of the in vivo gastrointestinal tract. The Diamod® simulator reproduces dissolution and online permeation of substances from the lumen of the small intestine to the sink compartments (blood stream).