Urokinase

Urokinase is a thrombolytic enzyme used to dissolve blood clots by converting plasminogen into plasmin, the key enzyme responsible for fibrin degradation. It is primarily indicated in the management of acute thrombotic events such as pulmonary embolism and catheter occlusion, where rapid restoration of blood flow is clinically required. By promoting fibrinolysis, urokinase helps to re-establish vessel patency and improve tissue perfusion in obstructed vascular systems.

Its use is typically reserved for hospital settings under strict monitoring due to the associated risk of bleeding, and dosing is carefully adjusted according to indication and patient condition.